Noxious input to the spinal cord is known to produce central sensitization, which consists of allodynia , exaggeration of pain, and punctuate hyperalgesia , extreme sensitivity to pain. Two types of mechanical hyperalgesia can occur: 1) touch that is normally painless in the uninjured surroundings of a cut or tear can trigger painful sensations (touch-evoked hyperalgesia), and 2) a slightly painful pin prick stimulation is perceived as more painful around a focused area of inflammation (punctuate hyperalgesia). Touch-evoked hyperalgesia requires continuous firing of primary afferent nociceptors, and punctuate hyperalgesia does not require continuous firing which means it can persist for hours after a trauma and can be stronger than normally experienced. In addition, it was found that patients with neuropathic pain, histamine ionophoresis resulted in a sensation of burning pain rather than itch, which would be induced in normal healthy patients. This shows that there is spinal hypersensitivity to C-fiber input in chronic pain. 
The Mitchell Report also stated that interviews were requested of five MLB players who had spoken out publicly on the steroid issue. Of these players, only one, Frank Thomas , was willing to be interviewed. The Mitchell Report stated that there was no evidence that any of these five had used performance-enhancing drugs. Curt Schilling , one of the four players who declined to interview with Mitchell, explained that he denied Mitchell's request because he "would have nothing to offer" Mitchell's investigation "other than personal opinion and hypotheticals."