Another great benefit which makes it the most sought after drug by steroid users is that it shows very low toxicity of the liver. Usually other steroids often cause high amount of liver toxicity in its users which make them less popular. However, with Anavar one also gets to experience no fluid retention in the joints during the steroid cycle. Being non-estrogenic in nature, Anavar also reduces the risk of virilization in women and gynecomastia in men. With Anavar, the weight increase after the steroid cycle is also very less, almost negligible.
Cimetidine was first marketed in the United Kingdom in 1976, and in the . in August 1977; therefore, it took 12 years from initiation of the H 2 receptor antagonist program to commercialization. By 1979, Tagamet was being sold in more than 100 countries and became the top-selling prescription product in the ., Canada, and several other countries. In November 1997, the American Chemical Society and the Royal Society of Chemistry in the . jointly recognized the work as a milestone in drug discovery by designating it an International Historic Chemical Landmark during a ceremony at SmithKline Beecham's New Frontiers Science Park research facilities in Harlow, England.