Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A 2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor , arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Although i’d wager most of it ends up in humans, it is still sold as a Vetrinary Steroid. As a vetrinary steroid it was never approved for human use, which makes it impossible to get a prescription for it in the usa. add this to the fact that it is a schedule 2 controlled substance in the united states and it becomes quite clear that the only way to get this steroid in the usa is to buy it on the black market. that being said, it is still relatively easy to obtain the real stuff. This is because smuggling almost 2x as much testosterone in the same space is a rather enticing thing, making it commonly available.