Great article. I found this while researching the IM Forums where you also have great info as well. I’ve read quite a bit all over the web. There’s so much confusion over this. I don’t have an opinion either for or against and can read between the lines/blurs/mumbo jumbo of what’s in print and find minimal reality of any facts supporting true positive results for any OTC T-booster product. This still leaves me in a quandary. I’m currently doing a cycle of 1-Andro/Anabolic Matrix and would like to keep my gains if any result from it. With all OTC products being pretty much useless for boosting test what would be a viable option for doing so as a PCT??
AB - Prenatal androgens are largely responsible for growth and differentiation of the genital tract and testis and for organization of the control mechanisms regulating male reproductive physiology and behavior. The aim of the present study was to evaluate the impact of inappropriate exposure to excess testosterone (T) during the first trimester of fetal development on the reproductive function, sexual behavior, and fertility potential of rams. We found that biweekly maternal T propionate (100 mg) treatment administered from Day 30–58 of gestation significantly decreased (P < ) postpubertal scrotal circumference and sperm concentration. Prenatal T exposure did not alter ejaculate volume, sperm motility and morphology or testis morphology. There was, however, a trend for more T-exposed rams than controls to be classified as unsatisfactory potential breeders during breeding soundness examinations. Postnatal serum T concentrations were not affected by prenatal T exposure, nor was the expression of key testicular genes essential for spermatogenesis and steroidogenesis. Basal serum LH did not differ between treatment groups, nor did pituitary responsiveness to GnRH. T-exposed rams, like control males, exhibited vigorous libido and were sexually attracted to estrous females. In summary, these results suggest that exposure to exogenous T during the first trimester of gestation can negatively impact spermatogenesis and compromise the reproductive fitness of rams.