Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A 2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor , arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Pharmaceutical Biochemist, with specialization in pharmaceutical processes and certification program in pharmaceutical administration at the Univarsidad Nacional Autonoma de México (UNAM), with experience in areas of new product development, stabilization, quality control and quality assurance, production management and maintenance. He previously worked for national and international companies, such as: CAFET, Carter Wallace, Lakeside Pharma, Roche, Lemery, Teva. Currently in Innovare R&D, collaborating as COO and chief of product development.