Inhalants are a group of chemicals including solvents, aerosols, adhesives, gases, cleaning agents, food products, anesthetics and volatile nitrites. These legal substances, most of which are found in everyday household products, are not normally thought of as drugs, but have drug-like effects on the user. The most familiar substances are paint and glue. But include nearly 600 common household, workshop and office products that are dangerous when inhaled. Those products include keyboard aerosol cleaners, felt-tip markers, spray paint, air freshener, butane and aerosol cooking sprays.
Detection of halotestin and other such illegal anabolic steroids in sports is achieved by GS-MS identification of urinary excreted anabolic steroids and their metabolites. In a test for halotestin, a dry residue obtained from a urine sample is dissolved in dimethylformamide and a sulfur trioxide-pyridine complex and is heated with 1% potassium carbonate solution. Halotestin and many of its metabolites contain two polar hydroxyl groups, leading to intermolecular hydrogen bonding that increases their boiling point and reduces volatility. In order to attain a gaseous sample for GC-MS, the products of hydrolysis are extracted, dissolved in methanol and derivatised to form volatile trimethylsilyl (TMS) esters by adding N -methyl- N -trimethylsilyl-trifluoroacetamide (MSTFA) and trimethylsilylimidazole (TMSImi).