Dextromoramide has a mean elimination half life of +/- minutes and volume of distribution of +/- L/kg.  Peak plasma levels are reached within - h after dosing, decline of plasma concentrations after the peak follow a biphasic pattern, with half-lives of - h for the first phase and - h for the terminal phase. While in about 40% of patients, half-lives from to h, in a monophasic manner. Less than % of the dose is excreted unchanged in urine within 8 h of administration. 
A series of new substituted 1,2,4-thiadiazoles were synthesized by appropriate route and screened for anticonvulsant, neurotoxic, and sedative-hypnotic activities. The structures of the synthesized compounds were confirmed by IR spectroscopy, C-13 NMR, and elemental (nitrogen and sulphur) analysis. After . injection of the compounds to mice or rate at doses of 30, 100, and 300 mg/kg, body weights were examined in the maximal electroshock-induced seizure (MES) and subcutaneous-pentylenetetrazole- (scPTZ-) induced seizure models after and 4 h. All the compounds showed protection against MES screen after h. Compounds were active at the doses of 100 mg/kg and 300 mg/kg dose . It may be concluded that the synthesized compounds were potent against MES-induced seizures than ScPTZ-induced seizures [ 79 ] (Structure (106) ).